Prognostic Factors in Phyllodes Tumor of the Breast: Are Immunohistochemical Biomarkers Useful? (2004)

 

 

Fibroadenoma and phyllodes tumor of the breast are both fibroepithelial tumors. Phyllodes tumor is an uncommon breast neoplasm constituting only 0.3 to 1.0% of all breast tumors. The median and mean age is about 45 years, about 15 years older than the median age of patients with fibroadenomas. Phyllodes tumors are rare in children and adolescents, and most lesion diagnosed as such in this age group are juvenile fibroadenomas. Phyllodes tumor can display locally destructive growth and can even metastasize. Phyllodes tumors are distinguished from fibroadenomas by their increased stromal cellularity and their leaflike architecture. Mostly, the stroma from fibroadenomas was polyclonal and the stroma of phyllodes tumors was monoclonal by PCR-based clonality assay. [via]
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