Processive Motor Protein as an Overdamped Brownian Stepper (2003)

 

 

The two headed motor protein kinesin appears to ‘‘walk’’ along the biopolymer microtubule in 8 nm steps. There is ample justification for a model where the motion of the detached head to the next docking site on the biopolymer is described as ratcheted diffusion. The forward reorientation of an attached head can be conceived of as a power stroke. A model that is based on these premises can accurately predict parameters of motor protein motion. When a human is walking, the physics involves mass, gravity, and inertia. Most power is consumed by the repeated acceleration as the foot that was in touch with the ground is brought forward to a position in front of the torso. Friction plays only a minor role in the energetics. [via]
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